Human Health and Disease NEET PYQs (2005–2026) with Solutions

10 solved Human Health and Disease PYQs

Real NEET and AIPMT questions from this chapter, newest first. Try each one, then open the answer and the step-by-step explanation.

1. Question 1 (NEET 2026)

   NEET 2026MediumPathogens and Diseases

   The following are the stages of life cycle of Plasmodium. Arrange the stages in the proper order: A. The parasites reproduce asexually in RBCs, bursting the cells. B. The parasites reproduce asexually in liver cells, bursting the cells and releasing into blood. C. Gametocytes develop in RBCs. D. Sporozoites reach the liver through the blood. E. Female mosquito injects sporozoites into humans during bite. Choose the correct answer from the options given below:

   1. AOption A: E, D, B, A, C
   2. BOption B: A, B, C, D, E
   3. COption C: C, A, B, D, E
   4. DOption D: E, C, D, B, A

   Show answer & explanationHide answer & explanation

   Correct answer: (A) E, D, B, A, C

   Explanation

   Plasmodium enters as sporozoites → reaches liver → multiplies in liver cells → infects RBCs and multiplies → gametocytes form in RBCs.

2. Question 2 (NEET 2026)

   NEET 2026MediumDrug, Alcohol and Tobacco Abuse

   Match List I with List II: Choose the correct answer from the options given below:

   1. AOption A: A-III, B-II, C-IV, D-I
   2. BOption B: A-II, B-III, C-I, D-IV
   3. COption C: A-II, B-III, C-IV, D-I
   4. DOption D: A-III, B-I, C-I, D-IV

   Show answer & explanationHide answer & explanation

   Correct answer: (C) A-II, B-III, C-IV, D-I

   Explanation

   Nicotine stimulates adrenal release of catecholamines; morphine acts as a sedative and analgesic; heroin is a depressant; cocaine induces euphoria and increased energy.

3. Question 3 (NEET 2026)

   NEET 2026EasyPrimary and secondary lymphoid organs

   Which of the following are secondary lymphoid organs? (a) Bone marrow (b) Tonsils (c) Spleen (d) Thymus Choose the correct answer from the options given below:

   1. AOption A: (a) and (b) only
   2. BOption B: (b) and (c) only
   3. COption C: (b) and (d) only
   4. DOption D: (a) and (d) only

   Show answer & explanationHide answer & explanation

   Correct answer: (B) (b) and (c) only

   Explanation

   Primary lymphoid organs are where immature lymphocytes differentiate into antigen-sensitive lymphocytes: the bone marrow and the thymus. After maturation, lymphocytes migrate to secondary lymphoid organs, where they interact with antigens and proliferate. These are the spleen, lymph nodes, tonsils, Peyer's patches of the small intestine and the appendix. So the secondary lymphoid organs here are tonsils (b) and spleen (c), option (B).

4. Question 4 (NEET 2026)

   NEET 2026EasyPassive immunity: colostrum antibodies

   Colostrum, secreted by mother during initial days of lactation, is abundant in ________.

   1. AOption A: IgG
   2. BOption B: IgM
   3. COption C: IgA
   4. DOption D: IgD

   Show answer & explanationHide answer & explanation

   Correct answer: (C) IgA

   Explanation

   NCERT states that the yellowish fluid colostrum, secreted by the mother during the initial days of lactation, has abundant antibodies (IgA) to protect the infant. This is an example of passive immunity, since ready-made antibodies are given to the infant. (The foetus receives IgG through the placenta.) Hence option (C).

5. Question 5 (NEET 2026)

   NEET 2026EasyDrugs: opioids

   Which of the following is used as an effective sedative and painkiller for treating post-surgery patients?

   1. AOption A: Interferon
   2. BOption B: Antibiotics
   3. COption C: Morphine
   4. DOption D: Anti-retroviral drugs

   Show answer & explanationHide answer & explanation

   Correct answer: (C) Morphine

   Explanation

   Morphine is an opioid extracted from the latex of the poppy plant Papaver somniferum. NCERT states that morphine is a very effective sedative and painkiller and is very useful in patients who have undergone surgery. Interferons are proteins that protect non-infected cells from viral infection, antibiotics kill or retard disease-causing microbes, and anti-retroviral drugs are used to manage HIV infection. Hence option (C).

6. Question 6 (NEET 2026)

   NEET 2026EasyLife cycle of Plasmodium (malaria)

   Which of the following statements is correct about Plasmodium?

   1. AOption A: Reproduces sexually in liver cells
   2. BOption B: Reproduces sexually in RBCs
   3. COption C: Gametocytes develop in mosquito gut
   4. DOption D: Fertilization takes place in mosquito gut

   Show answer & explanationHide answer & explanation

   Correct answer: (D) Fertilization takes place in mosquito gut

   Explanation

   Sporozoites injected by the female Anopheles mosquito reach the liver cells, where the parasite multiplies asexually; it then attacks RBCs and again reproduces asexually there, causing rupture of RBCs. So options (A) and (B) are wrong. Sexual stages (gametocytes) develop in the RBCs of the human host, not in the mosquito, so option (C) is wrong. When a female Anopheles bites an infected person, the gametocytes enter the mosquito, and fertilisation and further development take place in the mosquito's stomach (gut) to form sporozoites, which are stored in the salivary glands. Hence option (D).

7. Question 7 (NEET 2025)

   NEET 2025MediumCancer

   Neoplastic characteristics of cells refer to : A. A mass of proliferating cell B. Rapid growth of cells C. Invasion and damage to the surrounding tissue D. Those confined to original location Choose the correct answer from the options given below:

   1. AOption A: A, B only
   2. BOption B: A, B, C only
   3. COption C: A, B, D only
   4. DOption D: B, C, D only

   Show answer & explanationHide answer & explanation

   Correct answer: (B) A, B, C only

   Explanation

   Neoplastic cells show uncontrolled proliferation, rapid growth, and invasion of surrounding tissues. Cells confined to the original location are benign and not characteristic of malignant neoplasia.

8. Question 8 (NEET 2025)

   NEET 2025MediumImmunity and Vaccines

   After maturation, in primary lymphoid organs, the lymphocytes migrate for interaction with antigens to secondary lymphoid organ(s) / tissue(s) like: A. thymus B. bone marrow C. spleen D. lymph nodes E. Peyer's patches Choose the correct answer from the options given below :

   1. AOption A: B, C, D only
   2. BOption B: A, B, C only
   3. COption C: E, A, B only
   4. DOption D: C, D, E only

   Show answer & explanationHide answer & explanation

   Correct answer: (D) C, D, E only

   Explanation

   Secondary lymphoid organs include spleen, lymph nodes, tonsils, and Peyer's patches. Thymus and bone marrow are primary lymphoid organs.

9. Question 9 (NEET 2025)

   NEET 2025EasyImmunity and Vaccines

   Which of the following type of immunity is present at the time of birth and is a non-specific type of defence in the human body?

   1. AOption A: Acquired Immunity
   2. BOption B: Innate Immunity
   3. COption C: Cell-mediated Immunity
   4. DOption D: Humoral Immunity

   Show answer & explanationHide answer & explanation

   Correct answer: (B) Innate Immunity

   Explanation

   Innate immunity is present from birth and provides non-specific defense against pathogens.

10. Question 10 (NEET 2024)

    NEET 2024EasyPathogens and Diseases

    Match List I with List II : Choose the correct answer from the options given below:

    1. AOption A: A-III, B-I, C-IV, D-II
    2. BOption B: A-II, B-IV, C-III, D-I
    3. COption C: A-I, B-III, C-II, D-IV
    4. DOption D: A-IV, B-III, C-I, D-II

    Show answer & explanationHide answer & explanation

    Correct answer: (D) A-IV, B-III, C-I, D-II

    Explanation

    Typhoid is caused by the bacterium Salmonella typhi. Leishmaniasis is caused by protozoans of the genus Leishmania. Ringworm is a fungal infection, while filariasis is caused by nematode worms. Therefore, the correct matching is A-IV, B-III, C-I, D-II.